Actually I always build my cities on the grid and according to the production chains. Because I always play on highest difficulty, I need a specific layout to avoid traffic jams. So actually I’m doing sort of the opposite of what you are doing. My cities always end up looking like circuit boards. Here is an old screenshot from a different forum post:
That being said, I also want to try out a much more organic style where I ditch the grid and build everything in small villages, medium towns and maybe one or two big cities. All connected by a more realistic road network. I imagine it can look pretty amazing.
Do you mind sharing a few screenshots of your place? There’s also the Post a picture of your city thread that would love to have it.