I tried this with both a saved game and a new one:
1- Buildings no longer show an icon overlay for missing items. For example building without power no longer show the red icon with yellow thunderbolt . This applies to all resources.
2- These shortcuts do not work: P, C, T. I remapped them to the same keys with no luck.
3- LOD looks rough like anti aliasing is not working.
Add to this list, certain animations are broken. Some of my mines move in a very blocky fashion while other miners of the same type do not. Also, the game does not (and perhaps never did) remember the name of my city when I do a manual save, even if I’ve manually saved it before.